# Cisterna Biologics — High quality mRNA for therapeutic application

```yaml
url: "https://forg.to/companies/cisterna-biologics"
website: "http://www.cisternabx.com"
industry: "Healthtech"
company_size: "1-10 employees"
headquarters: "San Diego, USA"
is_hiring: false
open_roles: 0
verified: false
created: 2026-07-23
```

## About Cisterna Biologics

Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics – quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few

## Links

- Website: http://www.cisternabx.com
- Forg: https://forg.to/companies/cisterna-biologics

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